Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Functional and Biochemical Indicators of Pneumoconiosis in Mice: Comparison with Rats.
Author Hatch, G. E. ; Raub, J. A. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/311;
Stock Number PB85-224541
Additional Subjects Pneumoconiosis ; Volcanic ejecta ; Respiratory diseases ; Mice ; Rats ; Laboratory animals ; Indicator species ; Reprints ; Bioindicators ; Mount Saint Helens
Library Call Number Additional Info Location Last
NTIS  PB85-224541 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 13p
Mice were injected intratracheally with silica or Mt. St. Helens volcanic ash (0.2 mg/g body weight) and examined 6 months later for changes in lung function, histology, and hydroxyproline content. Results were compared with a similar study using rats. Mice injected with volcanic ash showed significant changes only in wet lung weights. Those injected with silica showed an approximate doubling of lung wet weight and dry weight and hydroxyproline content. Larger increases were seen if lymph nodes were left attached. Lung compliance, total lung capacity and the shape of the pressure-volume curve of the lung were changed as much as 22% in the silica treated mice. A mild degree of fibrosis with no dense lung consolidation was noted microscopically in silica treated mice. In contrast, silica treated rats showed dense lung consolidation, 3-5 fold increases in lung weights and hydroxyproline content, and up to 40% reductions in pulmonary function measurements.