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RECORD NUMBER: 14 OF 71

OLS Field Name OLS Field Data
Main Title Female Reproductive and Developmental Toxicology: Overview and Current Approaches.
Author Kamrin, M. A. ; Carney, E. W. ; Chou, K. ; Cummings, A. ; Dostal, L. A. ;
CORP Author Michigan State Univ., East Lansing. Dept. of Animal Science. ;Michigan Univ., Ann Arbor. School of Public Health. ;Dow Chemical Co., Midland, MI. Toxicology Research Lab. ;Rochester Univ., NY. Dept. of Obstetrics and Gynecology.;Environmental Protection Agency, Research Triangle Park, NC. Reproductive Toxicology Branch.
Publisher c1994
Year Published 1994
Report Number EPA-68-D2-0056; EPA/600/J-94/537;
Stock Number PB95-148995
Additional Subjects Reproduction ; Toxicology ; Teratogens ; Pregnancy ; Females ; Glutathione ; Environmental pollutants ; Fertilization ; Fetus ; Placenta ; Lactation ; Maternal-fetal exchange ; Cell differentiation ; Cocaine ; Cadmium ; Methylmercury compounds ; Gap junctions ; Reprints ;
Holdings
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Status
NTIS  PB95-148995 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 22p
Abstract
In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental and reproductive toxicology and only a limited number of validated tests to assay effects of toxicants on various parts of the reproductive and developmental cycle. This article reviews the current state of knowledge on this topic and also explores a variety of techniques for assessing female reproductive and developmental toxicity. These include an assay of the state of intercellular communication among the embryo, fetus and placenta; protocols for assessing toxicity in early pregnancy; and techniques for evaluating the role of glutathione in protecting the conceptus from xenobiotics.