Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Inhalation Exposure to Methyl 'tert'-Butyl Ether (MTBE) Using Continuous Breath Analysis.
Author Gordon, S. M. ;
CORP Author Battelle, Columbus, OH. Atmospheric Science and Applied Technology.;Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab.
Publisher Feb 2003
Year Published 2003
Report Number EPA-68-D-99-011; EPA/600/R-05/095;
Stock Number PB2006-110285
Additional Subjects Toxicity ; Gasoline vapors ; Health hazards ; Air pollution effects(Humans) ; Public health ; Chronic exposure ; Ethanol fuels ; Fuel mixtures ; Data analysis ; Inhalation exposure ; Quality control ; Modeling ; Blood ; Total absorbed dose ; Residence times ; Breath ; Continuous breath analysis ; Methyl tert-butyl ether (MTBE)
Library Call Number Additional Info Location Last
NTIS  PB2006-110285 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/20/2006
Collation 94p
Methyl tert-butyl ether (MTBE) was first introduced in the U.S. as a synthetic gasoline additive in the 1970s. The uptake of MTBE by inhalation has been measured in exhaled breath under controlled conditions using integrated sampling techniques. Several studies, including some based on the analysis of exhaled breath, have demonstrated significant dermal absorption of chloroform and trichloroethylene while showering or bathing, and the dose is roughly comparable to that resulting from inhalation. Because of the dynamic equilibrium between the concentration of a volatile organic compound (VOC) in the blood and its concentration in exhaled breath,25 breath measurements can be used to estimate body burden and to detect changes in body burden with time. Most previous measurements of human breath concentrations of VOCs to determine the dose resulting from inhalation exposure to the pollutant in air have, however, relied on the use of integrated sampling methods and subsequent batch analysis. This has limited the number of samples that are typically collected in such exposure studies to about four during the uptake phase and usually no more than about twelve during the decay phase, thus reducing the reliability of data designed to address these issues. The purpose of the present study was to use the real-time breath measurement technology determine more precisely than previous studies the residence times in various physiological compartments for MTBE in blood and breath. The study was also designed to provide analogous on DBCM and on the blood/breath ratios for MTBE and DBCM. A secondary purpose was analyze the data in an attempt to develop a model for MTBE that allows for the inclusion of a mucous membrane component, if appropriate, since previous work has suggested that this may important component of MTBE distribution in the body.