Record Display for the EPA National Library Catalog

RECORD NUMBER: 316 OF 4521

OLS Field Name OLS Field Data
Main Title Augmentation of Sulfate Ion Absorption from the Rate Lung by Heavy Metals.
Author Charles, Jeffrey M. ; Gardner, Donald E. ; Coffin, David L. ; Menzel., Daniel B. ;
CORP Author Duke Univ. Medical Center, Durham, N.C.;Health Effects Research Lab., Research Triangle Park, N.C.
Year Published 1977
Report Number EPA-68-02-2436; EPA/600/J-77/086;
Stock Number PB-278 585
Additional Subjects Absorption(Biology) ; Sulfates ; Lung ; Metals ; Air pollution ; Contaminants ; Interactions ; Respiration ; pH ; Ions ; Absorption(Biology) ; Rats ; Laboratory animals ; Reprints ; Heavy metals ; Particulates
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NTIS  PB-278 585 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract
The effect of heavy metal cations in enhancing the absorption of sulfate ions from the airways of the rat lung was studied. The cations investigated included Cd(2+), Co(2+), Hg(2+), Ni(2+), Fe(3+), Mn(2+), and Zn(2+). The cations exhibited differing efficacies. Co(2+), Hg(2+), Cd(2+), and Ni(2+) produced maximal effect at 0.1 nmol/lung, while Fe(3+) and Zn(2+) were the least effective, reaching maximal effect at 10.0 nmol/lung. An exception was Mn(2+), which did not alter absorption. Hydrogen ion concentrations departing from physiological pH values (4.4-9.4) enhanced sulfate ion absorption. Exposure of rats to a NiCl2 aerosol of 480 micrograms of Ni/cu m for 2 hr prior to the determination of sulfate ion absorption led to a 12.0 plus or minus 2.7% enhancement of absorption. These results suggest a possible correlation between the irritant potential associated with inhalation of a specific sulfate salt and the rate at which sulfate ions are absorbed from the lung. (Copyright (c) 1977 by Academic Press, Inc.)