Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Microinjection of Dynorphin into the Hippocampus Impairs Spatial Learning in Rats.
Author McDaniel, K. L. ; Mundy, W. R. ; Tilson., H. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Lab. of Molecular and Integrative Neuroscience.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/234;
Stock Number PB91-117044
Additional Subjects Hippocampus ; Learning ; Rats ; Memory ; Histology ; Reprints ; Microinjections ; Dynorphin ; Naloxone ; Dose-response relationships ; Endogenous substances receptors
Library Call Number Additional Info Location Last
NTIS  PB91-117044 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 9p
The effect of hippocampal dynorphin administration on learning and memory was examined in spatial and nonspatial tasks. Bilateral infusion of dynorphin A(1-8)(DYN; 10 or 20 micrograms in one microliter) into the dorsal hippocampus resulted in dose-related impairment of spatial working memory in a radial maze win-stay task. Subsequent experiments found that acquisition of a reference memory task in the water maze was impaired by DYN injections (20 micrograms/microliter) in the dorsal hippocampus, but not in the ventral hippocampus, and that this impairment could be blocked by naloxone. In a nonspatial task, posttraining DYN injections in the dorsal hippocampus had no effect on retention of step-through passive avoidance. These results suggest that dynorphin specifically interferes with spatial learning and memory, and that this effect is mediated by opioid receptors in the dorsal hippocampus.