||Learning and Memory Deficits in Rats Following Exposure to 3,3'-Iminodipropionitrile.
Peele, D. B. ;
Allison, S. D. ;
Crofton, K. M. ;
||NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Learning disorder ;
Avoidance learning ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The effects on learning and memory produced by beta, beta prime-iminodipropionitrile (IDPN) were examined in rats 4 weeks after dosing. IDPN (600 mg/kg) prevented acquisition of a olfactory discrimination task and disrupted performance of passive avoidance conditioning in separate groups of animals. The disruptive effects on passive avoidance conditioning were dosage dependent. Rats from both control and treated groups were then tested using a standard hot-plate test. The results suggest that treatment with IDPN did not produce the observed effects on learning and memory by altering sensitivity to painful, external stimuli. In summary, administration of IDPN is capable of producing profound and long lasting disruption of learning and memory in rats. (Copyright (c) 1990 by Academic Press, Inc.)