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RECORD NUMBER: 12 OF 37

OLS Field Name OLS Field Data
Main Title Effects of Dopaminergic Drugs on Working and Reference Memory in Rats.
Author Bushnell, P. J. ; Levin, E. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Duke Univ. Medical Center, Durham, NC. Dept. of Psychiatry.
Publisher Aug 93
Year Published 1993
Report Number EPA/600/J-93/404;
Stock Number PB93-236412
Additional Subjects Dopaminergic agents ; Memory ; Rats ; Motor activity ; Amphetamines ; Cognition ; Animal behavior ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB93-236412 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 14p
Abstract
Occupational exposure to styrene monomer has been associated with cognitive dysfunction in humans, and changes in dopaminergic function have been suggested to underly effects of repeated exposure to styrene monomer in animals. The study was designed to determine whether styrene and/or dopaminergic drugs affect working and reference memory in animals. Male Long-Evans rats were administered styrene by gavage at 4.5 - 6.5 months of age, and subsequently trained to perform an appetitive operant task which allowed daily quantification of working memory (accuracy of spatial delayed nonmatching-to-position), reference memory (accuracy of visual discrimination), perseverative responding (position bias) and motor function (choice lever press latencies and nosepoke inter-response times during delay). Styrene alone did not affect acquisition or any measure of performance on this task. The effects of the dopamine reuptake inhibitor d-amphetamine (0.3 - 1.0 mg/kg), the D1 agonist SKF 38393 (1.0 - 3.0 mg/kg), the D1 antagonist SCH 23390 (0.01 - 0.03 mg/kg), the D2 agonist quinpirole (0.01 - 0.056 mg/kg), and the D2 antagonist raclopride (0.056 - 0.177 mg/kg) were then assessed in control and styrene-treated rats.