Record Display for the EPA National Library Catalog

RECORD NUMBER: 484 OF 1865

OLS Field Name OLS Field Data
Main Title In vitro Teratology.
Author Schwetz, B. A. ; Morrissey, R. E. ; Welsch, F. ; Kavlock, R. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/314;
Stock Number PB92-124700
Additional Subjects Meetings ; Teratogenic compounds ; Toxicology ; Screening ; In vitro analysis ; Validity ; Nomenclature ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-124700 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/24/1992
Collation 6p
Abstract
The purpose of the In Vitro Teratology Conference was to (1) reevaluate the need for and use of in vitro teratology assays, (2) examine the validation process for in vitro tests, and (3) discuss progress in the validation of in vitro teratology screens. Participants enthusiastically supported further development of short-term in vivo and in vitro systems both as pre-screens for developmental toxicity and as experimental systems to explore mechanisms of action of toxicants. The group strongly endorsed the development of an updated reference list ('gold standard') of known developmental toxicants and non-toxicants as essential to further progress in developing and validation pre-screening efforts. Independently, an expert group should further evaluate the performance characteristics for a validated pre-screen. The limits of mechanistic investigations need to be clearly defined. Finally, too few in vitro teratology pre-screens have been evaluated under multiple-laboratory conditions with common agreed-upon test agents to draw firm conclusions regarding the merit and reproducibility of in vitro teratology pre-screens.