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RECORD NUMBER: 16 OF 78

OLS Field Name OLS Field Data
Main Title Comments on Recent Data for Particle Deposition in Human Nasal Passages.
Author Martonen, T. B. ; Zhang, Z. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Rhode Island Univ., Kingston. Dept. of Mechanical Engineering.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/122;
Stock Number PB93-181105
Additional Subjects Particles ; Air pollution effects(Humans) ; Nose(Anatomy) ; Pharynx ; Particle size ; Mathematical models ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-181105 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/23/1993
Collation 10p
Abstract
The deposition of inhaled particles within human nasal passages has important toxicologic and pharmacologic applications. However, experimental data quantitating factors affecting particle deposition are rare. The authors have evaluated findings from investigations employing either replica nasopharyngeal (NP) casts or surrogate model airways and compared them to each other and to human subject results. For ultrafine particles, studies using casts and models are incompatible, measured deposition values from the latter being lower by an entire order of magnitude. Possible sources of discrepancies between the data are suggested herein. Studies with diverse NP replicates, however, have yielded consistent deposition data over a wide particle size range, about 0.005 - 7 micrometers. Cast experiments underestimate, but in a systematic manner, in vivo information over a 0.5 - 3 micrometers interval. It is recommended, therefore, that NP replica cast data, rather than NP model airway data, be used to simulate human passages. For extrapolation modeling purposes, an original empirical formula based upon a logistic theory is derived which describes deposition over a particle size range of three orders of magnitude. (Copyright (c) 1992 Pergamon Press Ltd.)