||Intox Labs., Inc., Redfield, AR.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Oleylamine was evaluated for subchronic toxicity in Sprague-Dawley rats (4/sex/dose group) receiving dermal applications of 0, 0.3, 1.5, or 3% oleylamine in mineral oil on the shaved back, 5 days/week for 2 weeks. These concentrations of oleylamine correspond to doses of 0, 12.5, 62.5 and 125 mg/kg bw/day, respectively. Oleylamine at a concentration of 0.3% induced mild to moderate skin irritation, whereas concentrations of 1.5% and higher produced moderate to severe irritation, occasionally progressing to hardening and sloughing of the skin. Rats in the 1.5% and 3% groups were sensitive to touch. Body weight of males was significantly reduced in the 1.5% (p < 0.02) and 3% (p < 0.04) groups. Food consumption, expressed on a per-weight basis, was not significantly affected by treatment with oleylamine.