Record Display for the EPA National Library Catalog
RECORD NUMBER: 19 OF 2109
|OLS Field Name||OLS Field Data|
|Main Title||2 Phenoxyethanol: Two-week Dermal Probe Study in Female New Zealand White Rabbits to Assess Hematological Effects with Cover Letter.|
|CORP Author||Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 2-phenoxyethanol (122-99-6) ; Subchronic Toxicity ; Mammals ; Rabbits ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 122-99-6|
Subchronic toxicity was evaluated in groups of 10 female New Zealand White rabbits exposed to 2-phenoxyethanol for 14 consecutive days at a level of 0 or 0.91 ml/kg/day as an occluded dose to clipped, intact skin. Mortality was observed in 7 rabbits by day 8 of the experiment. Clinical observations included discoloration of the skin at the test site. Necropsy revealed hemoglobinuria; pale livers; dark kidneys and spleens; decreased hemoglobin, PCV and RBC values; increased erythrocyte indices, nucleated RBC's, leukocytes and erythrocytes; and regenerative hemolytic anemia due to intravascular hemolysis of RBC's.