Record Display for the EPA National Library Catalog

RECORD NUMBER: 27 OF 28

OLS Field Name OLS Field Data
Main Title Toxicological Investigationof Maleic Anhydride, Lot No. QB1151 with Cover Letter.
CORP Author Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1984
Report Number 878214766
Stock Number OTS-0206655
Additional Subjects Health effects ; Toxicity ; Laboratory animals ; Acute ; Lethal doses ; Signs and symptoms ; Dose levels ; Mammals ; Rats ; Oral ; Gavage ; Maleic anhydride ; CAS No 108-31-6
Holdings
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Status
NTIS  OTS-0206655 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 10/16/2009
Collation 1288p
Abstract
In an acute toxicity study, male and female Sprague-Dawley rats (2 males and 3 females/group, except highest-dose level group which had 4 males and 1 female) were given single gavage exposures to maleic anhydride (as a 10% solution/suspension in corn oil). Dose levels of 316, 398, 501, and 631 mg/kg resulted in the deaths of 0, 1, 3, and 4 animals, respectively (duration of observation period was not reported although the survival time was reported to be one to four days). The LD50 is 495 (410 to 580) mg/kg. Toxic symptoms observed included loss of appetite, diarrhea, and increasing weakness. Gross pathology observed at autopsy included renal and liver congestion, and inflammation of the gastric mucosa.