Record Display for the EPA National Library Catalog
RECORD NUMBER: 15 OF 28
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Chronic Dietary Administration of Maleic Anhydride with Cover Letter dated 09/08/1992.|
|CORP Author||ITT Research Inst., Lanham, MD.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Toxic substances ; Maleic anhydride ; Chronic toxicity ; Carcinogenicity ; Mammals ; Rats ; Oral ; Diet ; CAS No 108-31-6|
Maleic anhydride was evaluated for toxicologic and/or carcinogenic effects in male and female Fischer 344 rats following dietary administration at levels of 100, 32, and 10 ag/kg/day. A control group received only the basal diet (Wayne Laboratory Meal). The criteria evaluated for compound related effects included: mortality, gross and behavioral signs of toxic or pharmacologic effects, body weights, food and compound consumption, clinical laboratory analysis (hematology, biochemistry, urinalyses), ophthalmology, neurological signs, organ weights and organ/100 g body weight, and gross and microscopic pathology.