||Evidence That Drug-Resistant Alloreactive T Cells May Contribute to Human Graft Rejection.
Stanford, W. L. ;
Strauss, G. H. S. ;
Finn., O. J. ;
||Duke Univ., Durham, NC.;National Institutes of Health, Bethesda, MD.;Environmental Protection Agency, Washington, DC.
T lymphocytes ;
Homologous transplantation ;
Graft rejection ;
Immunosuppressive agents ;
Drug resistance ;
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The objective of the study was to determine whether resistance to immunosuppressive drugs by transplant recipient's T cells could contribute to continued graft rejection, in spite of immunosuppressive therapy. The T cell lines used in the series of experiments were originally established from T cells that had infiltrated kidney or liver grafts and initiated rejections in patients receiving immunosuppressive drugs, including the purine analogue azathioprine (AZ). The authors have used a proliferation assay and the Strauss-Albertini test to analyze the T cell lines. Both assays use 6-thioguanine (6-TG), an amino derivative of AZ, as the selective agent to measure the resistance to AZ. (Copyright (c) 1990 by Williams and Wilkins.)