Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Alteration of Cellular Interactions in the Immune System: Natural Killer Activity and N Lymphocytes.
Author Burleson, G. R. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-68-02-4450; EPA/600/D-87/302;
Stock Number PB88-106414
Additional Subjects Immunology ; Neoplasms ; Viral diseases ; Lymphocytes ; Killer cells(Natural) ; Immune system ; Suppressor cells ; NK(Natural killer)
Library Call Number Additional Info Location Last
NTIS  PB88-106414 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 56p
N lymphocytes, like interferons, have three major biological functions: (1) antitumor activity; (2) antiviral activity; and (3) immunoregulatory activity. Antitumor activity is also referred to as natural killer (NK) activity which represents the non-MHC-restricted lysis of NK-sensitive tumor cells by effector cells obtained from a nonimmunized host. N lymphocytes play a pivotal role in a network of immune functions. The review discusses the (1) properties of natural killer activity, (2) importance of natural killer activity against tumor cells, (3) importance of N lymphocytes in viral infections, (4) regulation of natural killer activity by cytokines, (5) alteration of natural killer activity by suppressor cells, and (6) alteration of natural killer activity by chemicals.