||Initial Submission: Draft Pathology Report (Terminal Kill) in 13-Week Inhalation Toxicity Study in the Rat with 13-Week Treatment-Free Period, with Cover Letter dated 12/07/1999. (Sanitized).
||UOP, Inc., Des Plaines, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Lymph nodes ;
Laboratory animals ;
Respiratory system ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
There were treatment-related changes in the lungs and bronchial lymph nodes of all treated group terminal kill animals. Microscopically, the findings in the lung were characterised by mild to moderate histiocytosis/proteinosis associated with perivascular cuffing/pneumonitis and increased peribronchial lymphoid response. Lymphoid hyperplasia and minor histiocyte foci were also found in the bronchial lymph nodes. A no observable effect level (NOEL) was not established.