||Responses of Subjects with Chronic Obstructive Pulmonary Disease after Exposures to 0.3 PPM Ozone.
Kehrl, H. R. ;
Hazucha, M. J. ;
Solic, J. J. ;
Bromberg, P. A. ;
||North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Respiratory diseases ;
Air pollution effects(Humans) ;
Chronic obstructive lung disease
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The authors previously reported (1982) that the respiratory mechanics of intermittently exercising persons with chronic obstructive pulmonary disease (COPD) were unaffected by a 2-h exposure to 0.2 ppm ozone. Employing a single-blind cross-over design protocol, 13 white men with nonreversible COPD were randomly exposed on two consecutive days for 2 h to air and 0.3 ppm ozone. During exposures, subjects exercised for 7.5 min every 30 min; ventilation and gas exchange measured during exercise showed no difference between exposure days. Pulmonary function tests (spirometry, body plethysmography) obtained before and after exposures were unchanged on the air day.