Main Title |
Hyperactivity and Hypoactivity Produced by Lesions to the Mesolimbic Dopamine System. |
Author |
Koob, George F. ;
Stinus, Luis ;
Moal, Michel Le ;
|
CORP Author |
Salk Inst., San Diego, CA. Arthur Vining Davis Center for Behavioral Neurobiology.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1981 |
Report Number |
EPA-R-806777; EPA-600/J-81-579; |
Stock Number |
PB82-248014 |
Additional Subjects |
Amphetamines ;
Dopamine ;
Drugs ;
Amines ;
Responses ;
Rats ;
Laboratory animals ;
Radio frequencies ;
Toxicity ;
Reprints ;
Lesions ;
Locomotor activity ;
Hyperactivity ;
Hypoactivity
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-248014 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
21p |
Abstract |
Spontaneous locomotor activity and the locomotor response to amphetamine and apomorphine were studied in rats subjected to either radiofrequency(RF), 6-hydroxydopamine (6-OHDA) of both RF and 6-OHDA lesions of the mesolimbic dopamine (DA) system. Large 6-OHDA lesions of the ventral tegmental area (VTA) or of the nucleus accumbens (N.Acc) produced hypo-activity in the open field, a complete blockade of the locomotor stimulating effects of D-amphetamine, and a profound supersensitive response to apomorphine as measured by a significant increase in locomotor activity as compared to sham-operated animals. |