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RECORD NUMBER: 2 OF 10

OLS Field Name OLS Field Data
Main Title Effect of Gavage Vehicle on Hepatotoxicity of Carbon Tetrachloride in CD-1 Mice: Corn Oil versus Tween-60 Aqueous Emulsion (Journal Version).
Author Condie, L. W. ; Laurie, R. D. ; Mills, T. ; Robinson, M. ; Bercz, J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Computer Sciences Corp., Falls Church, VA.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/475;
Stock Number PB89-106884
Additional Subjects Corn oil ; Carbon tetrachloride ; Toxicity ; Toxic substances ; Liver ; Pathology ; Chlorine organic compounds ; Laboratory animals ; Toxicology ; Dose-response relationships ; Liver function tests ; Enzymes ; Vehicles ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB89-106884 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 9p
Abstract
The investigation was conducted to evaluate the effect of corn oil gavage on the subchronic hepatotoxicity of carbon tetrachloride (CCl(4)). Male and female CD-1 mice were gavaged with 0, 1.2, 12, and 120 mg/kg CCl(4) in either corn oil or 1% Tween-60 vehicles once daily for five consecutive days per week for 90 days. The study revealed that the hepatotoxicity was greater in the corn oil vehicle groups of mice than in the Tween-60 groups. Increases in serum enzyme activities were detected in the 12 mg/kg CCl(4) corn oil male and female groups but not in the corresponding Tween-60 groups. The experimental findings indicate that the corn oil vehicle lowered the no-observed-adverse-level (NOAEL) from CCl(4) exposure by an order of magnitude (from 12 mg/kg to 1.2 mg/kg) and also enhanced the hepatoxicity of CCl(4) in the high dose treatment groups. (Copyright (c) 1986 by the Society of Toxicology.)