Record Display for the EPA National Library Catalog
RECORD NUMBER: 1504 OF 1791Main Title | Targeting Functional Centers of the Ribosome [electronic resource] / | ||||
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Type | EBOOK | ||||
Author | Davidovich, Chen. | ||||
Publisher | Springer Berlin Heidelberg, | ||||
Year Published | 2011 | ||||
Call Number | QD433-436 | ||||
ISBN | 9783642169311 | ||||
Subjects | Life sciences ; Chemistry, Organic ; Nucleic acids ; Biochemistry | ||||
Internet Access |
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Collation | XIV, 74 p. online resource. | ||||
Notes | Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
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Contents Notes | Introduction -- Methods -- Results -- Discussion. This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself. |