Main Title |
Mode of action of cyclodiene insecticides / |
Author |
Crowder, Larry A.
|
CORP Author |
Arizona Univ., Tucson. Dept. of Entomology.;Health Effects Research Lab., Research Triangle Park, N.C. |
Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, |
Year Published |
1976 |
Report Number |
EPA/600-1-76-008; EPA-R-800384; PB251670 |
Stock Number |
PB-251 670 |
OCLC Number |
07762770 |
Subjects |
Insecticides ;
Amidines ;
Toxaphene
|
Additional Subjects |
Insecticides ;
Toxicology ;
Pesticides ;
Chlorine aliphatic compounds ;
Terpenes ;
Chlorohydrocarbons ;
Halohydrocarbons ;
Nervous system ;
Metabolism ;
Excretion ;
Rats ;
Insects ;
Laboratory animals ;
Experimental data ;
Physiological effects ;
Toxaphene
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-76-008 |
c.1 |
Headquarters Library/Washington,DC |
02/27/2014 |
ELBD ARCHIVE |
EPA-600-1-76-008 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD |
EPA 600-1-76-008 |
|
AWBERC Library/Cincinnati,OH |
08/26/2016 |
NTIS |
PB-251 670 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
ix, 75 pages ; 28 cm. |
Abstract |
The report contains information concerning the mode of action, excretion, and metabolism of the cyclodiene insecticides. Toxaphene was the primary candidate for investigation with major emphasis on the mammalian system. Excretion of 36Cl-toxaphene was studied in the laboratory rat. Upon extraction, most of the radioactivity occurred in the water fractions of urine and feces as ionic chloride, indicating considerable metabolism of toxaphene. Occurrence of radioactivity in several tissues of Leucophaea maderae was determined after injections of 36Cl-toxaphene. Uptake of .00001M 36Cl-toxaphene in subcellular particles of ventral nerve cord and brain was studied and showed significant levels in the larger cell fragments. The toxicity syndrome of toxaphene to Gambusia affinis was divided into five stages, and the residue level at each stage was determined. Excretion was not observed. Metabolic alteration of toxaphene appeared to be minimal. Ventral nerve cords of Periplaneta americana and L. maderae showed increased nerve activity as viewed electrophysiologically when exposed to toxaphene. Toxaphene appeared to be a neurotoxicant. |
Notes |
"January 1976." "EPA/600-1-76-008." "Project no. R-800384." Includes bibliographical references. |