CORP Author |
Litton Bionetics, Inc., Bethesda, MD.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Abstract |
The mutagenicity of crotonaldehyde was evaluated in Salmonella tester strains TA1535, TA1537, TA1538, TA98 and TA100, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary bacterial toxicity determinations, crotonaldehyde was tested for mutagenicity at concentrations of 0.005, 0.01, 0.10, 1.0, 5.0 and 10.0 ul/plate using the agar incorporation method. Crotonaldehyde did not produce a positive response in any bacterial tester strain, either with or without metabolic activation. The investigators reported crotonaldehyde was toxic to all bacterial strains at concentrations of 1, 5 and 10 ul/plate. |