Record Display for the EPA National Library Catalog

RECORD NUMBER: 38 OF 42

OLS Field Name OLS Field Data
Main Title Tissue Distribution of P32-Labeled Parathion.
Author Fredriksson, Torsten ; Bigelow., Jerry K. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-280 013
Additional Subjects Pesticides ; Insecticides ; Toxicology ; Enzyme inhibitors ; Cholinesterase inhibitors ; Phosphorus organic compounds ; Chlorohydrocarbons ; Tissues(Biology) ; Autoradiography ; Labeled substances ; Absorption(Biology) ; Accumulation ; Rats ; Laboratory animals ; Parathion ; Reprints ; Toxic substances ; Organs ; Bioaccumulation ; Metabolites
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-280 013 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 5p
Abstract
The tissue distribution of P32-labeled parathion has been investigated by means of an autoradiographic technique applied to sections of whole mice. It was found that the material was absorbed very slowly from the subcutaneous deposit. The level of radioactivity in blood was low during the whole period of observation. The highest activity appeared in the salivary glands and cervical brown fat. Liver, kidney, and adipose tissues showed high uptake of radioactivity, and fairly high activity was found in gastric and intestinal walls, thyroid, spleen, and lungs. Less activity was noted in the central nervous system, musculature, and bone marrow. The labeled material was mainly excreted by the kidneys and not in bile or via the intestinal mucosa. The relationship between the distribution of the material and the sequence in which systemic symptoms appear in parathion intoxications has been pointed out. The fact that the actual tissue distribution of a cholinesterase inhibitor need not necessarily follow the pattern indicated by the enzyme inhibition has been stressed.