Record Display for the EPA National Library Catalog

RECORD NUMBER: 32 OF 42

OLS Field Name OLS Field Data
Main Title Studies on the Percutaneous Absorption of Parathion and Paraoxon. II. Distribution of 32P-Labelled Parathion within the Skin.
Author Fredriksson., Torsten ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-280 573; PB-280 565
Additional Subjects Absorption(Biology) ; Pesticides ; Insecticides ; Skin(Anatomy) ; Phosphorus organic compounds ; Distribution ; Labeled substances ; Autoradiography ; Experimental data ; Humans ; Laboratory animals ; Exposure ; Temperature ; Reprints ; Parathion ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester) ; Toxic substances ; Pesticide residues ; Bioaccumulation
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-280 573 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 10p
Abstract
The distribution of 32P-labelled parathion (E605, or diethyl 4-nitrophenyl thiononophosphate) within the skin following topical application for various periods of time was studied in excised skin from man, rat, rabbit, and cat. Two different approaches were chosen: (1a) determination of radioactivity in 25 consecutive cellulose tape strips from the surface of human skin, (1b) autoradiography of the same strips; and (2) autoradiography of skin sections with the use of four different techniques. Various factors influencing the autoradiograms were studied, special attention being paid to artefacts due to diffusion, type of radiation, and exposure time of the photosensitive material. It was found that parathion penetrates into hair follicles and sebaceous glands to some extent, but it was concluded that this is not necessarily the main route of absorption. There also was increasing activity below the epidermal layers, and transepidermal absorption is as likely. The results were discussed with special attention to the interpretation of the autoradiograms and to the implications for other studies of the percutaneous absorption of parathion.
Notes
Included in PB-280 565, Journal articles on toxicology. Group 12.