Record Display for the EPA National Library Catalog

RECORD NUMBER: 28 OF 42

OLS Field Name OLS Field Data
Main Title Regional Deposition of Inhaled Monodisperse Coarse and Fine Aerosol Particles in Small Laboratory Animals.
Author Raabe, O. G. ; Al-Bavati, M. A. ; Teague, S. V. ; Rasolt, A. ;
CORP Author California Univ., Davis.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/239;
Stock Number PB86-116555
Additional Subjects Aerosols ; Toxicology ; Laboratory animals ; Rodents ; Respiratory system ; Dosage ; Particulates ; Air pollution effects(Animals) ; Labeled substances
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB86-116555 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 20p
Abstract
The regional deposition of inhaled monodisperse insoluble particles of about 1, 3, 5, and 10 micrometers in activity median aerodynamic diameter was measured in four small rodent species including CF1 mice, golden Syrian hamsters, Fischer 344 rats and Hartley guinea pigs and in New Zealand rabbits. Near monodisperse aerosols of about 0.05 micrometers activity median diffusive diameter were also studied. The five species are commonly utilized in inhalation toxicology research. Monodisperse aerosols of fused aluminosilicate particles labeled with radioactive 169Yb were generated utilizing a modified vibrating liquid stream generator, reduced to Boltzmann charge equilibrium with a 85Kr discharge device, concentrated with a centripeter stage, fused in a 1200C quartz tube furnace, and delivered to a specially designed nose-only exposure system suitable for use with coarse particles as large as 10 micrometers. Twenty unanaesthetized animals (eight rabbits) were exposed simultaneously for up to 45 minutes to each aerosol particle size.