The paper discusses test methods to characterize particulate matter (PM) emission and deposition rates in a research house. In a room in the research house, specially configured for PM source testing, a high-efficiency particle air (HEPA)-filtered air supply system, used for positive pressurization of the room, minimizes PM infiltration from the outdoors and the rest of the house while a portable HEPA filter in the room reduces background PM prior to the start of source tests. A ceiling fan and portable air conditioner provide mixing and temperature control. Testing involves simultaneous real-time particle monitoring and integrated sampling. Particulate matter with aerodynamic diameters < 2.5 and 10 micrometers (PM2.5 and PM10, respectively) are collected on Teflon filters using size-selective cyclones operated at 16.7 L/min. Particle size distributions are measured with an electrical low-pressure impactor with 12 size fraction, from 0.030 to 10 micrometers in aerodynamic diameter.