Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 6

OLS Field Name OLS Field Data
Main Title Letter from Dow Corning Corp. to USEPA regarding Toxicity of Dimethyl Silicones and Siloxanes (Dow Corning 360 Fluid) with Attachments, dated 10/06/1995.
CORP Author Food and Drug Research Labs., Inc., Waverly, NY.; Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1995
Report Number OTS-86960000053
Stock Number OTS0558193
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Dimethyl silicones ; Siloxanes ; Laboratory animals ; Subchronic toxicity ; Mammals ; Rats ; Parenteral ; Subcutaneous ; Intramuscular ; Intraperitoneal ; Chronic toxicity ; Combined chronic toxicity/carcinogenicity ; Acute toxicity ; Rabbits ; Mice ; Monkeys ; CAS No 63148-62-9
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NTIS  OTS0558193 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 42p
Abstract
These studies first initiated in 1962 with the specific objective of providing additional evidence of systemic safety to add to the then sparse data provided by Rowe, Spencer and Bass (532) . The body of animal safety information developed by Ashley and co-workers adds immeasurably to the history of preclinical safety associated with DOW CORNING 360 Medical Grade Fluid administration. The absence of significant untoward symptomatology, or of any significant treatment related tissue pathology, are supportive to the findings of other investigators discussed in this submission. Seen in its critical dimensions, the findings in rodents, and in the subhaman primates, correlate in all respects with the observations derived from the extensive human experience available. The data have been prepared in a form to permit examination of elements with respect.