Record Display for the EPA National Library Catalog
RECORD NUMBER: 499 OF 1580
|OLS Field Name||OLS Field Data|
|Main Title||Estimating limiting risk levels from orally ingested DDT and dieldrin using an up-dated version of the Mantel-Bryan procedure /|
|CORP Author||George Washington Univ., Washington, D.C.;Environmental Protection Agency, Washington, D.C. Office of Toxic Substances.|
|Publisher||Office of Toxic Substances, Environmental Protection Agency,|
|Report Number||P4-01-02962; EPA 560/5-75-003|
|Stock Number||PB-243 009|
|Subjects||Dieldrin. ; DDT (Insecticide) ; Pesticides. ; Dichlorodiphenyltrichloroethane|
|Additional Subjects||Carcinogens ; DDT ; Dieldrin ; Laboratory animals ; Malignant neoplasms ; Ingestion(Biology) ; Dosage ; Experimental data ; Insecticides ; Chlorine organic compounds ; Liver ; Statistical analysis ; Biostatistics ; Tables(Data)|
|Local Library Info||
|Collation||17 pages : tables ; 28 cm|
Mathematical extrapolations of the upper limits on risk of cancer at various low levels of exposure to dieldrin and DDT are presented. The statistical model used is that described by Mantel, et al., Cancer Research, 35, 865-872, 1975, the so-called 'updated' Mantel-Bryan procedure. The data upon which the extrapolations are based are derived from the studies by Tomatis, et al., International Journal of Cancer, 10, 489-506, 1972 for DDT and by Walker, et al. Food and Cosmetics Toxicology, 11, 415-432, 1972 for dieldrin. Several alternative methods of treating the data are presented, and pesticide levels associated with various levels of risk are estimated. Certain precautions which must be observed in applying the 'updated' Mantel-Bryan technique are discussed.
"Prepared for the Office of Toxic Substances, Environmental Protection Agency." "Project Officer: Michael J. Prival." "Contract no. P4-01-02962." Bound with Supplement of the same title, dated December 27, 1974. Contract # P5-01-2598-J.