Record Display for the EPA National Library Catalog

RECORD NUMBER: 26 OF 1538

OLS Field Name OLS Field Data
Main Title Actions of pesticides and other drugs on the male reproductive system.
Author Thomas, John Arlen.
CORP Author West Virginia Univ. Medical Center, Morgantown. Dept. of Pharmacology.;National Environmental Research Center, Research Triangle Park, N.C. Pesticides and Toxic Substances Effects Lab.
Publisher US Environmental Protection Agency, Pesticides and Toxic Substances Effects Laboratory,
Year Published 1974
Report Number EPA/650/1-74-011; EPA-R-801650
Stock Number PB-237 381
Subjects Reproductive toxicology.
Additional Subjects Pesticides ; Reproductive system ; Sex hormones ; Insecticides ; Males ; Drugs ; Mice ; Laboratory animals ; Experimental data ; Toxicology ; Physiological effects ; Prostrate gland ; Liver ; DDT ; Dieldrin ; Chlorine organic compounds ; Metabolism ; Herbicides ; Androgens ; Tritium ; Carbamates ; Labeled substances ; Parathion ; T 2-4-5 ; Acetic acid/trichlorophenoxy ; Carbaryl
Holdings
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Status
NTIS  PB-237 381 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation viii, 34 pages : tables ; 27 cm.
Abstract
DDT or dieldrin or 2,4,5 T administered to male mice caused significant reductions in the assimilation of androgens by sex accessory organs. DDT or dieldrin altered the metabolism of testosterone in the prostrate gland and in the liver. DDT-3H administration led to the detection of significant amounts of tritium in male reproductive organs. Unlike the organochlorine-type pesticides, neither carbaryl nor parathion administration altered androgen metabolism. The administration of carbaryl-14C led to detectable amounts of radioactivity in several organs of reproduction including the seminal vesicles, prostate gland and testes. The fungicide thiophanate and thiophante-methyl had no affect upon spermatogenesis or upon the metabolism of androgens.
Notes
"EPA-650/1-74-011." "Grant No. R801650, ROAP No. 21AYL, Program Element No. 1EA078." Includes bibliographical references (pages 29-30). List of publications: pages 31-32. Microfiche.