Record Display for the EPA National Library Catalog

RECORD NUMBER: 1554 OF 1580

OLS Field Name OLS Field Data
Main Title Ultrastructure of Livers of Rats Fed DDT and Dieldrin.
Author Kimbrough, Renate D. ; Gaines, Thomas B. ; Lider., Ralph E. ;
CORP Author Food and Drug Administration, Chamblee, Ga.
Year Published 1970
Report Number found in PB-280 889
Stock Number PB-280 897, found in PB-280 889
Additional Subjects DDT ; Dieldrin ; Pesticides ; Toxicology ; Insecticides ; Bioassay ; Histology ; Liver ; Rats ; Ingestion(Biology) ; Dosage ; Diets ; Weight(Mass) ; Laboratory animals ; Experimental data ; Sleep ; Hypnotics and sedatives ; Pathology ; Mitochrondia ; Tables(Data) ; Reprints ; Toxic substances ; Hexobarbital ; Endoplasmic reticulum
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-280 897 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 10p
Abstract
Adult male rats were fed different dosage levels of DDT, dieldrin, or combination of the two. After eight weeks, hexobarbital sleeping time was determined in some of these rats. Livers of the other rats were examined with the light microscope and electron microscope. Hexobarbital sleeping time was significantly reduced in all treated rats compared to that of controls, but no difference was found between the various treated groups. Liver weights of all treated groups were significantly higher than those of the controls, and livers of rats fed the combination of DDT and dieldrin weighed significantly more than those rats given DDT or dieldrin alone. Morphological changes, including an increase in smooth endoplasmic reticulum and atypical mitochondria, were observed in all treated groups and were more pronounced in rats given both DDT and dieldrin.
Notes
contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.