Record Display for the EPA National Library Catalog

RECORD NUMBER: 1349 OF 1538

OLS Field Name OLS Field Data
Main Title Study of the chemical and behavioral toxicology of substitute chemicals in microtine rodents /
Author Cholakis, J. M. ; Wond, Laurence C. K. ; Lee, Cheng-Chun
Other Authors
Author Title of a Work
Wong, L. C. K.
Lee, Cheng-Chun
CORP Author Midwest Research Inst., Kansas City, MO.;Corvallis Environmental Research Lab., OR.
Publisher U.S. Corvallis Environmental Research Laboratory ; Available through National Technical Information Service,
Year Published 1978
Report Number EPA/600/3-78/082; EPA-68-01-4195; MRI-4298-B
Stock Number PB-288 416
Subjects Pesticides and wildlife. ; Pesticides--Toxicology. ; Microtus.
Additional Subjects Toxicology ; Pesticides ; Insecticides ; Herbicides ; Behavior ; Rodents ; Lethal dosage ; Diets ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Dose rate ; Sensitivity ; Females ; Males ; Concentration(Composition) ; Chlorine organic compounds ; Dieldrin ; Toxicity ; Tables(Data) ; Microtus ochrogaster ; Animal models ; Toxic substances ; Voles ; D 24 herbicide ; Acetic acid/dichlorophenoxy ; Phosphorothioic acid/0-0-(dimethyl-ester)-0-(nitrophenylester) ; Benzene/nitro-pentachloro ; Acetic acid/trichlorophenoxy ; T2-4-5 herbicide ; Propanil ; Propionanilide/dichloro ; Simazine ; Triazine/bis(ethylamino)-chloro ; Environmental chemical substitutes ; Microtus canicaudus ; Microtus pennsylvanicus ; Microtus montanus ; Dimethanonaphthalenes ; PCNB fungicide ; Methyl parathion ; Benzene/hexachloro ; Toluidine/trifluoro-dinitro-N-N-dipropyl
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB-288 416 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation vi, 54 pages ; 28 cm.
Abstract
Acute oral LD50 and 30-day dietary subacute LC50 studies of 10 selected pesticides were evaluated in microtine rodents. As a means to developing new animal model systems, four species of microtine rodents including Microtus ochrogaster (MO), Microtus canicaudus (MC), Microtus pennsylvanicus (MP) and Microtus montanus (MM) voles were used. The acute LD50 (median lethal dose in mg/kg) in all four species and the subacute LC50 (median lethal concentration in ppm) in MO and MC voles were computed using probit analysis. The data from both the acute and the 30-day subacute studies revealed that MC voles were approximately twice as sensitive to these pesticides as MO voles. Based on the acute studies, the overall order of pesticide toxicity was as follows: parathion > methyl parathion > dieldrin > 2,4-D > 2,4,5-T > simazine propanil = PCNB = HCB = trifluralin. The general order of species sensitivity was as follows: MC> MP> MO>MM. No apparent sex differences were observed in MP, MO or MM voles. In MC voles, the female appeared to be two- to three-fold more sensitive to methyl parathion than the male. Based on the 30-day subacute LC50 studies, the overall order of pesticide toxicity is as follows: dieldrin> parathion> methyl parathion> HCB> 2,4,5-T> PCNS> propanil. Based on LD50 values the laboratory rodents appear to be more susceptible to 2,4-D, dieldrin, methyl parathion, parathion, propanil, and 2,4,5-T, equally susceptible to HCB, PCNB, and trifluralin, and less susceptible to simazine than the MC voles.
Notes
Prepared for the U.S. Environmental Protection Agency, Office of Research and Development, Corvallis Environmental Research Laboratory, under Contract no. 68-01-4915. Includes bibliographical references (pages 19-20). Microfiche.