Record Display for the EPA National Library Catalog
RECORD NUMBER: 1326 OF 1519
|OLS Field Name||OLS Field Data|
|Main Title||Studies on the Percutaneous Absorption of Parathion and Paraoxon, III. Rate of Absorption of Parathion.|
|Author||Fredriksson., Torsten ;|
|CORP Author||Communicable Disease Center, Atlanta, Ga.|
|Stock Number||PB-280 570; PB-280 565|
|Additional Subjects||Absorption(Biology) ; Pesticides ; Insecticides ; Skin(Anatomy) ; Measurement ; Humans ; Laboratory animals ; In vivo analysis ; Experimental data ; Cats ; Insecticides ; Tables(Data) ; Labeled substances ; Cholinesterase inhibitors ; Physiology ; Phosphorus organic compounds ; Reprints ; Parathion ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester) ; Bioaccumulation ; Environmental health ; Toxic substances|
The rate of percutaneous absorption of parathion has been estimated in vivo by following the disappearance from a topical deposit of 32P-labelled material in the cat. There was a definite tendency towards inhibition of plasma cholinesterase activity in two cats, while a third animal failed to show this. The amount of radioactivity in the blood five hours after the application corresponded to 0.02 to 0.04 micrograms parathion per ml. It was concluded that parathion is very slowly absorbed, which makes this compound very unsuitable as a model substance in studies of the process of percutaneous absorption. The results have been discussed with special regard to experimental errors involved and to practical implications.
Included in PB-280 565,Journal articles on toxicology. Group 12.