Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Storage and Excretion of DDT in Starved Rats.
Author Dale, William E. ; Gaines, Thomas B. ; Hayes, Jr., Wayland J. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-279 726
Additional Subjects Insecticides ; DDT ; Pesticides ; Toxicology ; Bioassay ; Rats ; Laboratory animals ; Storage ; Excretion ; Experimental data ; Dosage ; Concentration(Composition) ; Brain ; Circulation ; Starvation ; Body weight ; Tissues(Biology) ; Tables(Data) ; Reprints ; Pesticide residues ; Bioaccumulation ; Toxic substances ; Metabolites ; Adipose tissue
Library Call Number Additional Info Location Last
NTIS  PB-279 726 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
It is well known that some poisons, such as lead when stored in sufficient amount, may be mobilized from storage with the result that clinical illness appears or recurs. This phenomenon was first demonstrated experimentally for DDT by Fitzhugh and Nelson (1947). They showed that rats that had been fed diets containing DDT at concentrations of 600 parts per million (ppm) or more showed marked tremors when they were deprived of food completely. Rats deprived of all food after being fed 200 or 400 ppm showed increased irritability but no tremors. It has been assumed that these clinical effects resulted from a mobilization of DDT concurrent with the mobilization of body fat, but the effect of starvation on the concentration of DDT in various tissues and excreta has not previously been measured. This paper reports the results of such measurements in rats that were starved and in suitable controls. The results confirm that DDT is, in fact, mobilized into the circulation and into the brain during starvation and thus explain the clinical effects.