Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title In vivo Inhibition of Chicken Brain Acetylcholinesterase and Neurotoxic Esterase in Relation to the Delayed Neurotoxicity of Leptophos and Cyanofenphos.
Author Soliman, S. A. ; Curley, A. ; Farmer, J. ; Novak, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/414;
Stock Number PB88-124599
Additional Subjects Toxicology ; Phosphorus organic compounds ; Nervous system disorders ; Insecticides ; Acetylcholinesterase ; Esterases ; Enzyme inhibitors ; Laboratory animals ; Chickens ; In vivo analysis ; Toxicity ; Reprints ; Organophosphorus compounds ; Insecticides/organophosphate ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-124599 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
An equimolal single dose (1 mmole/kg) of leptophos or cyanofenphos was given orally to chickens to assay the clinical and biochemical neurotoxic effects of these two organophosphorus insecticides. Parathion and TOCP at 2 and 1000 mg/kg of chicken body weight were tested in the same manner as negative and positive neurotoxicants, respectively. Three birds of each of five groups tested were sacrificed 1,2,3,7,14,21 and 28 days after treatment and the brains were taken for the biochemical tests. Acetylcholinesterase (AChE) and neurotoxic esterase (NTE) activities were determined in the brain microsomal fractions. In addition, the AChE activity in the brain soluble fractions was measured. (Copyright (c) 1986 by Chem-Orbital.)