Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Water Pollutants and Other Chemicals Upon the Activity of Lipase 'in vitro'.
Author Christensen, G. M. ; Riedel, B. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Year Published 1981
Report Number EPA-600/J-81-209;
Stock Number PB81-212185
Additional Subjects Lipase ; Toxicology ; Enzymes ; In vitro analysis ; Water pollution ; Activity ; Inhibition ; DDT ; Pesticides ; Reprints ; Water pollution effects ; Heavy metals ; Toxic substances ; NTISEPAORD
Library Call Number Additional Info Location Last
NTIS  PB81-212185 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Lipase preparations were treated in vitro with 100 chemicals of various classes, many of which are environmental pollutants, to determine their effect upon enzyme activity. The greatest inhibition was caused by mercuric ion and certain heavy metal cations; almost as inhibiting were pentachlorophenol, dicofol, 2,4,5-trichlorophenol, and DDT. Less inhibition was found with other inorganic salts, organo-metals, other organic chemicals, and some pesticides. Apart from dichromate ion, the anions studied had a low to negligible effect on lipase. A mixture of 10 inorganic salts had an approximately cumulative inhibition effect on enzyme activity. None of the chemicals studied caused a measurable activation of the enzyme.