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RECORD NUMBER: 11 OF 107

OLS Field Name OLS Field Data
Main Title Correlation between Neurotoxic Esterase Inhibition and Mipafox-Induced Neuropathic Damage in Rats.
Author Veronesi, B. ; Padilla, S. ; Lyerly, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/125;
Stock Number PB86-243243
Additional Subjects Rats ; Laboratory animals ; Neuropathology ; Reprints ; Esterase inhibition ; Mipafox ; Neurotoxicology
Holdings
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Status
NTIS  PB86-243243 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 12p
Abstract
The correlation between neuropathic damage and inhibition of neurotoxic esterase or neuropathy target enzyme (NTE) was examined in rats acutely exposed to Mipafox (N, N'-diisopropylphosphorodiamidofluoridate), a neurotoxic organophospate. Brain and spinal cord NTE activities were measured in Long-Evans male rats 1 hr post-exposure to various dosages of Mipafox (ip, 1-15 mg/kg). These data were correlated with histologically scored cervical cord damage in a separate group of similarly dosed rats sampled 14-21 days post-exposure. Those dosages (greater than or equal to 10 mg/kg) that inhibited mean NTE activity in the spinal cord greater than or equal to 73% and brain greater than or equal to 67% of control values produced severe (greater than or equal to 3) cervical cord pathology in 85% of the rats.