Record Display for the EPA National Library Catalog

RECORD NUMBER: 49 OF 338

OLS Field Name OLS Field Data
Main Title Comparative Stimulation of gamma HCH Metabolism by Pretreatment of Rats with gamma HCH, DDT, and DDT gama HCH.
Author Chadwick, R. W. ; Cranmer, M. F. ; Peoples., A. J. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Year Published 1970
Stock Number PB-277 608
Additional Subjects DDT ; Pesticides ; Insecticides ; Toxicology ; Metabolism ; Rats ; Ingestion(Biology) ; Toxicity ; Dosage ; Laboratory animals ; Experimental data ; Chlorine organic compounds ; Bioassay ; Cyclohexane/hexachloro ; Reprints ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB-277 608 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 1p
Abstract
Pretreatment of rats with gamma HCH, DDT, and DDT + gamma HCH accelerates the metabolism of gamma HCH. A single oral dose of 14C - gamma HCH was administered to all animals after a 2-week pretreatment period. The treated rats excreted significantly more radioactivity and stored significantly less 14C - gamma HCH than the control animals. Results of this study suggest that the mechanism by which gamma HCH induces its own degradation differs from the mechanism through which DDT stimulates gamma HCH metabolism.