||Chronic Effects of Dietary Exposure to Amosite Asbestos and Tremolite in F344 Rats.
McConnell, E. E. ;
Rutter, H. A. ;
Ulland, B. M. ;
Moore, J. A. ;
||National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Hazleton Labs. America, Inc., Vienna, VA.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
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Carcinogenesis bioassays of blocky (nonfibrous) tremolite and amosite asbestos alone or in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) were conducted with male and female Fischer 344 rats. The minerals were administered at a concentration of 1% in pelleted diet for the entire lifetime of the rats starting with the dams of the test animals. One group of amosite rats also received chrysotile asbestos via gavage during lactation. Group sizes varied from 100 to 250. No toxicity or increase in neoplasia was observed in the tremolite exposed rats compared to the controls. Significant increases (P<0.05) in the rates of C-cell carcinomas of the thyroid and monocytic leukemia in male rats were observed in amosite exposed groups. However, the biological significance of the C-cell carcinomas in relation to amosite asbestos exposure is discounted because of a lack of significance when C-cell adenomas and carcinomas were combined and the positive effect was not observed in the amosite plus preweaning gavage group.