Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Cardiovascular Effects of o,p'-DDD.
Author Cueto, Jr., Ciprian ;
CORP Author National Communicable Disease Center, Perrine, Fla. Pesticides Research Lab.
Year Published 1968
Stock Number PB-278 082
Additional Subjects Toxicology ; Pesticides ; Ingestion(Biology) ; Dogs ; Laboratory animals ; Experimental data ; Physiological effects ; Cardiovascular system ; Bioassay ; Reprints ; DDD insecticide ; Toxic substances ; Glucocorticoids
Library Call Number Additional Info Location Last
NTIS  PB-278 082 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 1p
Daily oral administration of o,p'-DDD to dogs produced glucocorticoid deficiency. This was demonstrated by a decreased plasma hydroxy corticosteroids (17 OHCS) and the abolition of ACTH-induced increase in 17 OHCS and decrease of eosinophiles. Plasma volume, Na+, K+, and blood pressure and heart rate were unaltered. After two weeks of treatment with o,p'-DDD the dogs were anesthetized for pharmacological evaluation. Blood pressure and heart contractile force and rate responses to graded doses of epinephrine and norepinephrine were determined in treated and in untreated dogs. As a final test, cardiac contractile force response to ouabain was determined.