Record Display for the EPA National Library Catalog
RECORD NUMBER: 28 OF 338
|OLS Field Name||OLS Field Data|
|Main Title||Biochemical Effects of Repeated Administration of p,p'-DDT on the Squirrel Monkey.|
|Author||Cranmer, M. ; Peoples, A. ; Chadwick., R. ;|
|CORP Author||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.|
|Report Number||found in PB-280 889|
|Stock Number||PB-280 895, found in PB-280 889|
|Additional Subjects||DDT ; Pesticides ; Toxicology ; Insecticides ; Ingestion(Biology) ; Biochemistry ; Monkeys ; Laboratory animals ; Experimental data ; Dosage ; Concentration(Composition) ; Lethal dosage ; Bioassay ; Liver ; Hematology ; Tables(Data) ; Physiological effects ; Enzymes ; Blood plasma ; Exposure ; Reprints ; Toxic substances|
p,p'-DDT was administered po in peanut oil to 5 groups of 6 squirrel monkeys at doses of 50, 5, 0.5, 0.05, and 0 mg/kg/day. Blood samples were taken weekly from each animal; several hematologic parameters were determined, and plasma amylase, aldolase, glutamic-pyruvic transaminase, and isocitric dehydrogenase were measured. Two monkeys from each group were killed after 2, 4, and 6 mo and in vitro liver homogenate enzyme activity was measured using p-nitroanisole and ethyl p-nitrophenyl phenylphosphonothioate as substrates. No discernible effects on hematologic values or plasma enzyme levels were observed. The stimulation of the 2 liver homogenate mixed-function oxidases was maximal after 2 mo treatment. There were no significant differences in the levels of homogenate enzyme activity at the 3 sacrifice periods. The monkeys given 50 mg/kg/day all died within 14 wk of starting treatment; deaths did not occur at the other doses.
contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.