Record Display for the EPA National Library Catalog

RECORD NUMBER: 11 OF 338

OLS Field Name OLS Field Data
Main Title Alterations in Liver Microsomal Metabolism of Parathion Caused by Chronic Administration of Dilantin, Chloroquine.
Author Davis, J. E. ; Cranmer, M. F. ; Peoples., A. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Year Published 1971
Stock Number PB-277 603
Additional Subjects Pesticides ; Drugs ; Toxicology ; Monkeys ; Rats ; Metabolism ; Liver ; Ribosomes ; Ingestion(Biology) ; Toxicity ; Quinolines ; Bioassay ; Quinoline/chloro-(((diethylamino)-methylbutyl)amino) ; Dilantin ; Chloroguine
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-277 603 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 1p
Abstract
Monkeys and rats were fed dilantin, chloroquine, or DDE in order to assess the effects of these compounds on liver microsomal metabolism of parathion and the inductive mechanisms involved. The feeding of dilantin and chloroquine affected neither the cytochrome P-450 level in, nor the parathion metabolism by, rat liver microsomes. DDE administratiion greatly increased the liver microsomal metabolism of parathion but had no effect on the cytochrome P-450 level.