The purpose of this document is to provide useful methods and guidance to support the application of sustainability indicators in EPA decision making, and particularly within the Office of Research and Developments (ORD) research programs. The primary target audience is EPA researchers, as well as Program and Regional Office staff, that have a need for measurement of progress in some aspect of sustainability. However, it is anticipated that external organizations will find this information useful, as well. Science provides the foundation for credible decision-making. Only through adequate knowledge about the risks to human health and ecosystems, and innovative solutions to prevent pollution and reduce risk, can we continue to enjoy a high quality life. With a better understanding of environmental risks to people and ecosystems, the U.S. Environmental Protection Agency can target the hazards that pose the greatest risks and anticipate environmental problems before they reach a critical level.