Record Display for the EPA National Library Catalog

RECORD NUMBER: 51 OF 349

OLS Field Name OLS Field Data
Main Title Assessment of the hazards of polybrominated biphenyls
Author Di Carlo, Frederick Joseph
Other Authors
Author Title of a Work
Siefter, Joseph.
DeCarlo, Vincent J.
CORP Author Environmental Protection Agency, Washington, D.C. Office of Toxic Substances.
Publisher U.S. Environmental Protection Agency,
Year Published 1978
Report Number EPA/560/6-77/037
Stock Number PB-285 532
OCLC Number 04754354
Additional Subjects Toxicology ; Industrial medicine ; Assaying ; Air pollution ; Water pollution ; Assessments ; Chlorine organic compounds ; Hazards ; Carcinogens ; Humans ; Fire resistant coatings ; Rats ; Bioassay ; Lethal dosage ; Laboratory animals ; Pharmacology ; Half life ; Exposure ; Food chains ; Production ; Carcinogenesis Polybrominated biphenyls ; Biphenyl/chloro ; Toxic substances ; Teratogenesis ; Bioaccumulation ; Environmental effects ; Occupational safety and health
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=910134NA.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJED  EPA 560-6-77-037 OCSPP Chemical Library/Washington,DC 01/01/1988
NTIS  PB-285 532 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 15 p.
Abstract
During their peak use period, PBBs represented under 1% of the total sales of fire retardant chemicals, and very probably would have escaped intensive study if they had not been mixed accidentally with animal feed preparations. Instead, international attention was drawn to PBBs by the state-supervised killing of over 35,000 cattle which had been contaminated with PBBs. Interestingly, low doses of PBBs exert a broad spectrum of toxicological, pharmacological, and biochemical effects despite low acute toxicity. These effects and the intensive bioaccumulation of PBBs derive from their structure and their consequent resistance of biotransformation and high solubility in fat. In rodents, PBBs are teratogenic, immunosuppressive, and potentially carcinogenic. In bovine, rodent, and avian species, PBBs reduce feed intake and induce mixed function oxidases of liver microsomes. The latter effect may be responsible for steroid level changes which underline hormonal toxicities observed in cows, mink, rats, and chickens. The effects of PBBs on humans are controversial, but data suggestive of immunological, skin, and liver disorders continue to accumulate. Concern about the clinical effects of PBB's is heightened by the knowledge that these compounds readily enter the fetus by crossing the placental barrier and can be transferred to newborn children after extensive passage into breast milk.
Notes
Includes references.