Main Title |
Immunologic Effects of Nickel: 2. Suppression of Natural Killer Cell Activity. |
Author |
Smialowicz, R. J. ;
Rogers, R. R. ;
Riddle, M. M. ;
Garner, R. J. ;
Rowe, D. G. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/011; |
Stock Number |
PB85-198281 |
Additional Subjects |
Nickel ;
Chlorides ;
Laboratory animals ;
Immunology ;
Mice ;
Dosage ;
In vivo analysis ;
Bioassay ;
Neoplasms ;
Melanoma ;
Cells(Biology) ;
Reprints ;
Inteferon
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-198281 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
A single intramuscular injection of nickel chloride (18.3 mg/kg) caused a significant reduction in murine splenic natural killer (NK) cell activity. This reduction in NK activity was not associated with a significant reduction in spleen cellularity nor in the production of suppressor cells. In a 4-hr 51Cr release assay, NK cell activity was suppressed in both CBA/J and C57BL/6J mice. Administration of the nickel dose (i.e., 18.3 mg/kg total) over a two week period also caused a significant reduction in NK cell activity. In an in vivo NK assay the clearance of 125I-iododeoxyuridine labeled YAC-1 tumor cells from the lungs of nickel-treated mice was significantly reduced compared with saline injected controls. Another in vivo correlate of nickel-induced NK suppression was observed in mice injected with the B16-F10 melanoma. |