Main Title |
Estimating the potency of mutagens : cytotoxicity as an obligatory consequence of mutagenicity / |
Author |
Carver, June H. ;
Branscomb, Elbert W. ;
Hatch., Frederick T.
|
Other Authors |
|
CORP Author |
California Univ., Livermore. Lawrence Livermore Lab.;Environmental Protection Agency, Washington, DC. Office of Energy, Minerals, and Industry.;Department of Energy, Washington, DC. |
Publisher |
Office of Energy, Minerals and Industry, U.S. Environmental Protection Agency, |
Year Published |
1979 |
Report Number |
EPA/600-7-79-172; UCRL-81690-REV-2; W-7405-ENG-48 |
Stock Number |
PB81-152894 |
OCLC Number |
53964402 |
Additional Subjects |
Mutagens ;
Toxicology ;
Bioassay ;
Identifying ;
Estimating ;
Screening ;
In vitro analysis ;
Hazards ;
Cells(Biology) ;
Cytotoxicity ;
Toxic substances
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJED |
EPA-600/7-79-172 |
|
OCSPP Chemical Library/Washington,DC |
01/30/2004 |
EKBD |
EPA-600/7-79-172 |
|
Research Triangle Park Library/RTP, NC |
01/02/2004 |
ELBD ARCHIVE |
EPA 600-7-79-172 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
NTIS |
PB81-152894 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
vii, 11 pages : charts ; 28 cm. |
Abstract |
Rapid and reliable screening methods are required for identifying environmental mutagens and estimating their mutagenic potency in preparation for use of more elaborate tests to assess the genetic risk to man. On theoretical grounds, one expects a certain minimum cytotoxic potency to correlate with mutagenic potency, particularly when the latter is measured using forward mutations that result in inactive gene products. Furthermore, as cells cannot divide unless a substantial fraction of their genome is functionally intact, mutagenic agents should also be obligatory cytotoxic agents, with a given mutagenicity conferring a certain irreducible cytotoxicity. The authors show here that the cytotoxic potency of 22 chemical mutagens is highly correlated with their mutagenic potency as assayed in five rodent and human in vitro cell systems. This relationship implies that the maximum potential mutagenic potency of such compounds may be reliably estimated from rapid and straightforward measurements of their cytotoxic potency, the latter defined as the failure of cultured cells to undergo continued cell division. The estimate is necessarily a maximum one, as an agent may exert cytotoxic effects by pathways indpendent of its mutagenic action. |
Notes |
EPA Project Officer: G. Rausa. U.S.D.O.E. Project Director: G. Stapleton. Biomedical Sciences Division, Lawrence Livermore Laboratory, University of California. "August, 1979." Includes bibliographical references (pages 9-11). "EPA/600-7-79-172." |