Main Title |
Immunotoxicology strategies for pharmaceutical safety assessment / |
Other Authors |
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Publisher |
Wiley, |
Year Published |
2008 |
OCLC Number |
216937167 |
ISBN |
9780470122389 (cloth); 0470122382 (cloth) |
Subjects |
Immunotoxicology ;
Immune system--Effect of drugs on ;
Toxicity testing ;
Drugs--Toxicology ;
Drug Toxicity--immunology ;
Drug Design ;
Drug Evaluation--methods ;
Immune System--drug effects ;
Immunotoxins--adverse effects ;
Risk Assessment ;
Sistema imune ;
Toxicologia ;
Immunpharmakologie ;
Arzneimitteldesign ;
Toxikologie ;
Klinisches Experiment ;
Immunotoxin ;
Arzneimittelnebenwirkung
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Internet Access |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
RC582.17.I47 2008 |
|
Research Triangle Park Library/RTP, NC |
08/21/2012 |
|
Collation |
xxviii, 402 p., [12] p. of plates : ill. (some col.) ; 25 cm. |
Notes |
Includes bibliographical references and index. |
Contents Notes |
Current regulatory expectations for immunotoxicologyy evaluation of pharmaceuticals / Kenneth L. Hastings -- Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans -- Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley -- Need for specialized immunotoxicity tests / Kazuichi Nakamura -- Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj -- T cell-dependent antibody response tests / Joseph R. Piccotti -- Natural killer cell assay and other innate immunity tests / Lisa Plitnick -- Cellular immune response in delayed-type hypersensitivity test / Karen Price -- Evaluation of drug effects on immune cell phenotypes / Laurie Iciek -- Functional cellular responses and cytokine profiles / Elizabeth R. Gore -- Application of flow cytometry in drug development / Padma Narayanan ... [et al.] -- Animal models of host resistance / Gary R. Burleson and Florence G. Burleson -- Approaches to evaluation of autoimmunity / Danuta J. Herzyk -- Differentiating between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho -- Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere -- Antidrug antibody responses in nonclinical studies and their implications / Barbara Mounho -- Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House -- Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski ... [et al.] -- Systemic hypersensitivity / Raymond Pieters -- Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier -- Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas -- Developmental immunotoxicity in nonhuman primates / Pauline L. Martin and Eberhard Buse -- Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski -- Animal models for preclinical comparative immunogenicity testing / Daniel Wierda -- T cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer -- Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes. |