Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Age-Dependent Effects of 6-Hydroxydopamine on Locomotor Activity in the Rat.
Author Erinoff, Lynda ; MacPhail, Robert C. ; Heller, Alfred ; Seiden, Lewis S. ;
CORP Author Chicago Univ., IL.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1978
Report Number EPA-600/J-79-138;
Stock Number PB82-117987
Additional Subjects Rats ; Laboratory animals ; Age ; Physiological effects ; Reprints ; Hydroxydopamines ; Locomotor activity
Library Call Number Additional Info Location Last
NTIS  PB82-117987 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 13p
This experiment examined the effects on locomotor activity of intraventricular 6-hydroxydopamine (6-OHDA) administered to developing and adult rats. 6-OHDA was administered subsequent to pargyline treatment at 3 and 6 days of age; or 6-OHDA was administered subsequent to desmethylimipramine (DNI) treatment (6-OHDA/DMI) at 3 and 6 days of age, 11 and 14 days of age, 20 and 23 days of age, or 46 and 48 days of age. Locomotor activity of vehicle-treated rats assessed in stabilimeter cages peaked between 14 and 16 days of age and subsequently declined to levels characteristic of the adult. Treatment with pargyline and 6-OHDA at 3 days of age, or 6-OHDA/DMI at 3 and 6 or 11 and 14 days of age, did not alter the early rise in locomotor activity but prevented the decline in activity normally seen during the third and fourth weeks of life. When tested as adults, locomotor activity was greater in rats that had been treated with 6-OHDA/DMI at 3 and 6 and at 11 and 14 days of age than in those that had been treated at 20 and 23 days of age. Treatment with 6-OHDA/DMI at 46 and 48 days of age was without significant effect on locomotor activity.