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RECORD NUMBER: 28 OF 43

OLS Field Name OLS Field Data
Main Title Initial Submission: Inhalation Pilot Study of Hydrogen Cyanide Exposure in Sprague-Dawley Rats with Cover Letter dated 07/23/92.
CORP Author Monsanto Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920007543
Stock Number OTS0545731
Additional Subjects Toxicology ; Health effects ; Hydrogen Cyanide ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 74-90-8
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NTIS  OTS0545731 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 30p
Abstract
Hydrocyanic acid (CAS No. 74-90-8) was evaluated for subacute inhalation toxicity in Sprague-Dawley rats (5/sex/group) administered whole-body exposures to a mean analytical concentration of 67.8 +/- 7.0 ppm for 6 hours on 3 consecutive days under dynamic conditions (2060-2200 L/min). An initial exposure was associated with hypoactivity, rapid shallow breathing, anoxia/hypoxia signs, and convulsions, followed by chromorhinorrhea, convulsions and varied signs of labored breathing. Survivors of 2 exposures exhibited rapid breathing and reduced mean bodyweight with a solitary male rat exhibiting arching of the back. Signs of toxicity associated with a third exposure were limited to hypoactivity and quick shallow breathing; mean daily bodyweight gains were restored. Mortality occurred either during or following an initial exposure in 1 and 2 males, respectively. Necropsy of these study decedents revealed cyanosis of the extremities, hemorrhagic lungs, lung and tracheal edema, blanching of the liver, chromorhinorrhea, urine-filled bladder, gaseous distention of the gastro-intestinal tract, and a solitary incidence of blood engorgement of the heart and surrounding vasculature. On terminal necropsy of study survivors, females exhibited slight to moderate hemorrhage (3/5) and grey discoloration (2/5) of the lung.