Record Display for the EPA National Library Catalog
RECORD NUMBER: 16 OF 43
|OLS Field Name||OLS Field Data|
|Main Title||Evaluation of the potential carcinogenicity of 1,2-diphenylhydrazine (122-66-7) /|
|CORP Author||Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.|
|Publisher||U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;|
|Report Number||EPA-68-03-3112; EPA-68-03-3182; EPA/600/8-91/126; OHEA-C-073-101|
|Additional Subjects||Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Hydrazine/diphenyl ; Carcinogenicity ; Dose-response relationships ; CAS Registry No: 122-66-7|
|Collation||19 pages ; 28 cm|
1,2-Diphenylhydrazine is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and although there are 'No Data' from human studies on 1,2-diphenylhydrazine, IARC reports that benzidine (a known human carcinogen) 'may be produced from 1,2-diphenylhydrazine by acidity in the stomach'. The potency factor (F) for 1,2-diphenylhydrazine is estimated to be 4.31 (mg/kg/day)-1, placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, 1,2-diphenylhydrazine is assigned a 'MEDIUM' hazard ranking.
Cover title. "June 1988." Includes bibliographical references. Microfiche.