||Acute Effects of 0.2 ppm Ozone in Patients with Chronic Obstructive Pulmonary Disease.
Solic, John J. ;
Hazucha, Milan J. ;
Bromberg, Philip A. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Respiratory diseases ;
Chronic obstructive lung disease ;
Air pollution effects(Humans)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Epidemiologic data suggest that patients with chronic obstructive pulmonary disease (COPD) might be more sensitive than normal persons to the respiratory effects of oxidant pollutant exposure. The study was designed to determine the response of patients with COPD to ozone. Thirteen white men with nonreversible airways obstruction of whom 8 were current smokers, were randomly exposed for 2 h to air and to 0.2 ppm ozone on 2 consecutive days using a single-blind crossover design. During either exposure, subjects exercised for 7.5 min every 30 min. Measures of respiratory mechanics obtained pre-exposure and postexposure were not significantly affected by either exposure.